HRID2211423

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18986

5-Methoxyindoleacetic acid

C11H11NO3

结构：COc1ccccc1[C@]1(O)CCC(c2ccccc2)(c2ccccc2)[C@H]2CNC[C@H]21.Cl

HCID70218598

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2[nH]cc(CC(=O)N3C[C@@H]4[C@H](C3)C(c3ccccc3)(c3ccccc3)CC[C@@]4(O)c3ccccc3OC)c2c1

HCID57039225

未命名化合物

收率 61.3%

PROCEDURE

实验过程

By working in accordance with Use Example 4, starting from 0.8 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-perhydroisoindol-4-ol hydrochloride and 0.41 g of (5-methoxy-3-indolyl)-acetic acid, 0.66 g of (3aS, 4S, 7aS)-7,7-diphenyl-2-[(5-methoxy-3-indolyl)-acetyl]-4-(2-methoxyphenyl)-perhydroisoindol-4-ol is obtained in the form of a beige foam.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c8334eac9f4d45e7b9e2de2c22e16e99
来源数据集: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05463077
来源说明: uspto-grants-1995_10

反应 SMILES

Cl.[C:2]1([C:8]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C@@H:16]3[C@@H:12]([CH2:13][NH:14][CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:32][O:33][C:34]1[CH:35]=[C:36]2[C:40](=[CH:41][CH:42]=1)[NH:39][CH:38]=[C:37]2[CH2:43][C:44](O)=[O:45]>>[C:26]1([C:8]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C@@H:16]3[C@@H:12]([CH2:13][N:14]([C:44](=[O:45])[CH2:43][C:37]4[C:36]5[C:40](=[CH:41][CH:42]=[C:34]([O:33][CH3:32])[CH:35]=5)[NH:39][CH:38]=4)[CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1