HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methoxyindoleacetic acid → (3aS,4S,7aS)-7,7-diphenyl-2-[(5-methoxy-3-indolyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methoxyindoleacetic acid | HCID 18986 | — |
| Reactant | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride | HCID 70218598 | — |
| Product | (3aS,4S,7aS)-7,7-diphenyl-2-[(5-methoxy-3-indolyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol | HCID 57039225 | 61.3% |
Reaction Steps
By working in accordance with Use Example 4, starting from 0.8 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-perhydroisoindol-4-ol hydrochloride and 0.41 g of (5-methoxy-3-indolyl)-acetic acid, 0.66 g of (3aS, 4S, 7aS)-7,7-diphenyl-2-[(5-methoxy-3-indolyl)-acetyl]-4-(2-methoxyphenyl)-perhydroisoindol-4-ol is obtained in the form of a beige foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05463077 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-c8334eac9f4d45e7b9e2de2c22e16e99 |
| Source note | uspto-grants-1995_10 |