HRID2211424

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID254166

1-Methyl-3-indoleacetic acid

C11H11NO2

结构：COc1ccccc1[C@]1(O)CCC(c2ccccc2)(c2ccccc2)[C@H]2CNC[C@H]21.Cl

HCID70218598

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1[C@]1(O)CCC(c2ccccc2)(c2ccccc2)[C@H]2CN(C(=O)Cc3cn(C)c4ccccc34)C[C@H]21

HCID67736900

未命名化合物

收率 58%

PROCEDURE

实验过程

By working in accordance with Use Example 4, starting from 0.75 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2methoxyphenyl)-perhydroisoindol-4-ol hydrochloride and 0.32 g of (1-methyl-3-indolyl)-acetic acid, 0.56 g of (3aS, 4S, 7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(1methyl-3-indolyl)-acetyl]-perhydroisoindol-4-ol is obtained in the form of a beige foam.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bb63887623e549f1a442b9ed193c5de4
来源数据集: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05463077
来源说明: uspto-grants-1995_10

反应 SMILES

Cl.[C:2]1([C:8]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C@@H:16]3[C@@H:12]([CH2:13][NH:14][CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:32][N:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]([CH2:42][C:43](O)=[O:44])=[CH:34]1>>[C:26]1([C:8]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C@@H:16]3[C@@H:12]([CH2:13][N:14]([C:43](=[O:44])[CH2:42][C:35]4[C:36]5[C:41](=[CH:40][CH:39]=[CH:38][CH:37]=5)[N:33]([CH3:32])[CH:34]=4)[CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1