2-(1-methyl-1H-indol-3-yl)acetic acid → (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(1-methyl-3-indolyl)acetyl)perhydroisoindol-4-ol

Participants

Reaction Steps

By working in accordance with Use Example 4, starting from 0.75 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2methoxyphenyl)-perhydroisoindol-4-ol hydrochloride and 0.32 g of (1-methyl-3-indolyl)-acetic acid, 0.56 g of (3aS, 4S, 7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(1methyl-3-indolyl)-acetyl]-perhydroisoindol-4-ol is obtained in the form of a beige foam.

Provenance & Evidence