Hydrazine hydrate (1:1) → (7-Methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride

HRID 2211434Notes

Reaction equation

HRID 2211434 reaction equation
[Cl:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1.O.[NH2:13][NH2:14]>C(O)C>[ClH:1].[CH3:11][C:8]1[C:4]2[N:5]=[CH:6][N:7]=[C:2]([NH:13][NH2:14])[C:3]=2[S:10][CH:9]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 27775864-Chloro-7-methylthieno(3,2-d)pyrimidine

Product 1

HCID 21960236(7-Methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochlorideYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 4-chloro-7-methylthieno[3,2-d]pyrimidine (4, 3.1 g, 17 mmol) and hydrazine monohydrate (3.5 mL, 72 mmol) in ethanol (34 mL) was heated at reflux for 1 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (3.2 g, 88% yield) as a white solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1 hour
  3. filtrationthe solid product was collected by vacuum filtration

Sources & evidence

ORD record
ord-3da2c064d6f248c991c45bdc18310db0
Source dataset
uspto-grants-2006_09
Patent number
USRE039267E1

Reaction notes

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