3-Pyridinecarboxaldehyde → HCID 69516952, compound

HRID 2211441Notes

Reaction equation

HRID 2211441 reaction equation
Cl.[Br:2][C:3]1[C:7]2[N:8]=[CH:9][N:10]=[C:11]([NH:12][NH2:13])[C:6]=2[S:5][CH:4]=1.[N:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH:20]=O)[CH:15]=1>C(O)C>[Br:2][C:3]1[C:7]2[N:8]=[CH:9][N:10]=[C:11]([NH:12][N:13]=[CH:20][C:16]3[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=3)[C:6]=2[S:5][CH:4]=1

Participants

4

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 21960238HCID 21960238, compound

Product 1

HCID 69516952HCID 69516952, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of (7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (168, 29 mg, 0.12 mmol) and 3-pyridinecarboxaldehyde (18 mg, 0.17 mmol) in ethanol (2 mL) was heated at reflux for 4 hours. After cooling to room temperature, the solid product was collected by vacuum filtration to yield 3-pyridinecarboxaldehyde(7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazone (32 mg, 81% yield) as a pale yellow solid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 4 hours
  3. filtrationthe solid product was collected by vacuum filtration

Sources & evidence

ORD record
ord-d07c5b8ca1024955b685f73fcfba7e93
Source dataset
uspto-grants-2006_09
Patent number
USRE039267E1

Reaction notes

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