Hydrochloric Acid → 3-Hydroxythiophene-2-carboxylic acid
Reaction equation
C(OCC1C(OC(=O)C)C(OC(=O)C)C(OC(=O)C)C([O:24][C:25]2[CH:29]=[CH:28][S:27][C:26]=2[C:30](=[O:39])NCC2C=CC=CC=2)O1)(=O)C.C[O-:41].[Na+].Cl>CO>[OH:24][C:25]1[CH:29]=[CH:28][S:27][C:26]=1[C:30]([OH:39])=[O:41]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 22 °C
Procedure
600 mg of 3,4,5-triacetoxy-6-(2-benzylcarbamoyl-thiophen-3-yloxy)-tetrahydro-pyran-2-ylmethyl acetate were dissolved in 40 ml of methanol, and 1.40 ml of a 30% strength methanolic sodium methanolate solution were added. The reaction mixture was stirred at 22° C. for 2 h, neutralized with 0.5 molar methanolic HCl solution and concentrated. The crude product was purified by column chromatography (SiO2, ethyl acetate/methanol=10:1).
Workup
- concentrationconcentrated
- customThe crude product was purified by column chromatography (SiO2, ethyl acetate/methanol=10:1)
Sources & evidence
- ORD record
- ord-9add939784274ca885f205fb2ab6e5da
- Source dataset
- uspto-grants-2006_09
- Patent number
- US07101856B2
Reaction notes
Loading…