Sulfuric Acid → Ethyl 3-(4-methylphenyl)-3-oxopropanoate

HRID 2211592Notes

Reaction equation

HRID 2211592 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6](=[O:14])[C:7]1[CH:12]=[CH:11][C:10](Cl)=[CH:9][CH:8]=1)[CH3:2].[CH3:16]NC(=N)S.OS(O)(=O)=O.NC1OC(C2C=CC(SC)=CC=2)=CC(=O)N=1>>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6](=[O:14])[C:7]1[CH:12]=[CH:11][C:10]([CH3:16])=[CH:9][CH:8]=1)[CH3:2]

Participants

5

Reactant 4

HCID 1118Sulfuric AcidHCID 101336Ethyl 3-(4-chlorophenyl)-3-oxopropanoateHCID 21962140HCID 21962140, compoundHCID 178485201HCID 178485201, compound

Product 1

HCID 292637Ethyl 3-(4-methylphenyl)-3-oxopropanoate

Procedure

The title compound was prepared from ethyl(4-chloro)benzoylacetate (5.0 g, 22 mmol) (obtained in preparation 2) and methylthiopseudourea.H2SO4 (3.31 g, 12 mmol) by following the procedure described in preparation 4, (0.573 g, 11.6%). MS m/z: 223 (M+). Preparation 6 Synthesis of 2-amino-6-(4-methylsulfanyl-phenyl)-1,3-oxazin-4-one

Workup

  1. customdescribed in preparation 4, (0.573 g, 11.6%)

Sources & evidence

ORD record
ord-78979f26236a4b67aa5edcd1ca3d81bb
Source dataset
uspto-grants-2006_09
Patent number
US07101873B2

Reaction notes

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