Trifluoroacetic acid → HCID 21961443, compound

HRID 2211660Notes

Reaction equation

HRID 2211660 reaction equation
[CH3:1][N:2]([CH3:22])[CH2:3][CH2:4][CH2:5][C:6]1[CH:7]=[C:8]([CH:18]=[CH:19][C:20]=1[F:21])[CH2:9][NH:10]C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:22][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][C:6]1[CH:7]=[C:8]([CH2:9][NH2:10])[CH:18]=[CH:19][C:20]=1[F:21]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21961372HCID 21961372, compound

Product 1

HCID 21961443HCID 21961443, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To [3-(3-Dimethylamino-propyl)-4-fluoro-benzyl]-Boc-amine (3.0 g, 10 mmol) in 100 mL of CH2Cl2 was slowly added TFA (10 mL). The resulting solution was stirred for 1 h, then concentrated. The residue was diluted with CH2Cl2 and aq. NaHCO3 solution. The organic layer was dried over Na2SO4 and concentrated to give the title compound. MS (ES+): 211 (M+H)+; (ES−): 209 (M−H). Calc'd C12H19FN2-210.29.

Workup

  1. concentrationconcentrated
  2. additionThe residue was diluted with CH2Cl2 and aq. NaHCO3 solution
  3. dry with materialThe organic layer was dried over Na2SO4
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-ec37e99677a1473096e4175a1183c9d4
Source dataset
uspto-grants-2006_09
Patent number
US07101868B2

Reaction notes

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