Lawesson's reagent → HCID 10310225, compound

HRID 2211682Notes

Reaction equation

HRID 2211682 reaction equation
[O:1]=[S:2]1(=[O:28])[CH:7]=[CH:6][CH:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=O)[CH:22]([F:24])[F:23])[O:16][C:15]3=[O:26])=[CH:10][C:9]=2[F:27])[CH2:4][CH2:3]1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:38])=CC=1>O1CCOCC1>[O:1]=[S:2]1(=[O:28])[CH:7]=[CH:6][CH:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][NH:20][C:21](=[S:38])[CH:22]([F:24])[F:23])[O:16][C:15]3=[O:26])=[CH:10][C:9]=2[F:27])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 10216447HCID 10216447, compound

Product 1

HCID 10310225HCID 10310225, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product of Example 9 (0.40 g, 0.956 mmol) and Lawesson's reagent (0.290 g, 0.717 mmol) in dioxane (5 ml) are heated at 80° C. overnight. The reaction mixture is evaporated to dryness and the residue purified by PTLC (10% MeOH/DCM) to give the title compound as solid. Rf (10% MeOH/DCM)=0.66.

Workup

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue purified by PTLC (10% MeOH/DCM)

Sources & evidence

ORD record
ord-a13dbf8c9c7649e998434d9820be4b09
Source dataset
uspto-grants-2006_09
Patent number
US07101874B2

Reaction notes

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