Hydrochloric Acid → HCID 21962581, compound

HRID 2211807Notes

Reaction equation

HRID 2211807 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][CH2:9][CH2:10][NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[C:6]2[CH:18]=[CH:19][C:20]([S:22][CH:23]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:24][C:25]([O:27]CC)=[O:26])=[CH:21][C:5]=2[O:4][CH2:3]1.[OH-].[Na+].Cl>C(O)C>[O:1]=[C:2]1[N:7]([CH2:8][CH2:9][CH2:10][NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[C:6]2[CH:18]=[CH:19][C:20]([S:22][CH:23]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:24][C:25]([OH:27])=[O:26])=[CH:21][C:5]=2[O:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21962565HCID 21962565, compound

Product 1

HCID 21962581HCID 21962581, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 3-({3-oxo-4-[3-(2-pyridinylamino)propyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}sulfanyl)-3-phenylpropanoate in ethanol is treated with an equimolar amount of 1N sodium hydroxide solution. The mixture is stirred at room temperature overnight. Then, the pH is brought to neutrality with 1N hydrochloric acid, the solvent is evaporated under reduced pressure and the residue is purified by filtration through a small pad of silica gel, eluting with a mixture of dichloromethane, methanol and acetic acid.

Workup

  1. customthe solvent is evaporated under reduced pressure
  2. filtrationthe residue is purified by filtration through a small pad of silica gel
  3. washeluting with a mixture of dichloromethane, methanol and acetic acid

Sources & evidence

ORD record
ord-c7b19cac041c4707a80d1cdec4dc5a54
Source dataset
uspto-grants-2006_09
Patent number
US07101876B2

Reaction notes

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