HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → HCID 21962569, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Sodium Bisulfate | HCID 516919 | — |
| Reactant | HCID 21045488 | HCID 21045488 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | 2-Dimethylaminopyridine | HCID 21885 | — |
| Product | HCID 21962569 | HCID 21962569 | — |
Reaction Steps
To a stirred solution of 5-(dimethyl-t-butylsilyl)oxymethyl-2-(4-methoxybenzylamino) phenol in anhydrous dichloromethane, triethylamine and dimethylaminopyridine at 0° C. and under nitrogen atmosphere, chloroacetyl-chloride is added. The mixture is refluxed for 10 h, poured into aqueous sodium bisulfate, extracted with dichloromethane and the product isolated by flash chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07101876B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-b0bf1b623ad640279ae17420df6d2395 |
| Source note | uspto-grants-2006_09 |