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HRID2211808

反应详情

EQUATION

反应方程式

HRID 2211808 的结构方程式

REACTANTS

反应物

3
结构：O=C(Cl)CCl
HCID6577

Chloroacetyl chloride

C2H2Cl2O

结构：O=S(=O)([O-])O.[Na+]
HCID516919

Sodium hydrogen sulfate

HNaO4S

结构：COc1ccc(CNc2ccc(CO[Si](C)(C)C(C)(C)C)cc2O)cc1
HCID21045488

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CN2C(=O)COc3cc(CO[Si](C)(C)C(C)(C)C)ccc32)cc1
HCID21962569

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

3
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

结构：CCN(CC)CC
溶剂HCID8471

Triethylamine

C6H15N

结构：CN(C)c1ccccn1
溶剂HCID21885

2-Dimethylaminopyridine

C7H10N2

PROCEDURE

实验过程

To a stirred solution of 5-(dimethyl-t-butylsilyl)oxymethyl-2-(4-methoxybenzylamino) phenol in anhydrous dichloromethane, triethylamine and dimethylaminopyridine at 0° C. and under nitrogen atmosphere, chloroacetyl-chloride is added. The mixture is refluxed for 10 h, poured into aqueous sodium bisulfate, extracted with dichloromethane and the product isolated by flash chromatography.

WORKUP

后处理

  1. temperatureThe mixture is refluxed for 10 h
  2. extractionextracted with dichloromethane
  3. customthe product isolated by flash chromatography