Hydrochloric Acid → HCID 21045422, compound

HRID 2211832Notes

Reaction equation

HRID 2211832 reaction equation
C(OC([NH:8][C@H:9]([CH2:22][C:23]1[CH:28]=[C:27]([F:29])[C:26]([F:30])=[CH:25][C:24]=1[F:31])[CH2:10][C:11]([N:13]1[CH2:19][CH2:18][CH2:17][NH:16][C:15](=[O:20])[C@H:14]1[CH3:21])=[O:12])=O)(C)(C)C.[ClH:32]>O1CCOCC1>[ClH:32].[NH2:8][C@H:9]([CH2:22][C:23]1[CH:28]=[C:27]([F:29])[C:26]([F:30])=[CH:25][C:24]=1[F:31])[CH2:10][C:11]([N:13]1[CH2:19][CH2:18][CH2:17][NH:16][C:15](=[O:20])[C@H:14]1[CH3:21])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69290248HCID 69290248, compound

Product 1

HCID 21045422HCID 21045422, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(3R)-4-[(3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoyl]hexahydro-3-methyl-2H-1,4-diazepin-2-one from Step E was treated with 4N hydrogen chloride in dioxane, stirred for 2.5 h and evaporated to yield the title compound. LC/MS 344.1 (M+1).

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-8c475edc3810483f825b3e7a68b16206
Source dataset
uspto-grants-2006_09
Patent number
US07101871B2

Reaction notes

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