Hydrochloric Acid → HCID 11723827, compound

HRID 2211836Notes

Reaction equation

HRID 2211836 reaction equation
C(OC([NH:8][C@H:9]([CH2:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[F:30])[CH2:10][C:11]([N:13]1[CH2:19][CH2:18][CH2:17][N:16]([CH3:20])[C:15](=[O:21])[CH2:14]1)=[O:12])=O)(C)(C)C.Cl>O1CCOCC1>[NH2:8][C@H:9]([CH2:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[F:30])[CH2:10][C:11]([N:13]1[CH2:19][CH2:18][CH2:17][N:16]([CH3:20])[C:15](=[O:21])[CH2:14]1)=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69289064HCID 69289064, compound

Product 1

HCID 11723827HCID 11723827, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(3R)-4-[(3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,5-trifluorophenyl)butanoyl]hexahydro-3-methyl-2H-1,4-diazepin-2-one from Step E was treated with 4N hydrogen chloride in dioxane, stirred for 4 h and evaporated to yield the title compound.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-e1fe87e0c949479189d82ed98c1c1d67
Source dataset
uspto-grants-2006_09
Patent number
US07101871B2

Reaction notes

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