反应详情

N-[4-(2-chloro-ethyl)-2-methyl-phenyl]-N-propyl-acetamide was prepared according to the general method as outlined in Preparation 43 starting from N-[4-(2-chloro-ethyl)-2-methyl-phenyl]-acetamide (0.400 g, 1.89 mmol) and iodopropane (0.230 mL, 2.36 mmol). After chromatographic purification, the product was isolated as a viscous oil (0.432 g, 1.701 mmol). Yield=90%. MS (APCI): 254 [M+H]+; 1H NMR (400 MHz, CDCl3D2O) δ 7.13 (bs, 1H), 7.07 (bd, J=7.77 Hz, 1H), 7.00 (d, J=7.77 Hz, 1H), 4.8 (bs, H2O/D20), 4.03–3.91 (m, 1H), 3.71 (t, J=8.12 Hz, 2H), 3.11–2.99 (m, 3H), 2.20 (s, 3H), 1.72 (s, 3H), 1.64–1.41 (m, 2H), 0.87 (t, J=6.34 Hz, 3H).

1. customAfter chromatographic purification