3-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride → HCID 21963175, compound

HRID 2211928Notes

Reaction equation

HRID 2211928 reaction equation
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[C:7]([CH:15]([CH3:17])[CH3:16])[CH:6]=1)=[O:4].Cl.[N:19]1([C:25]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[S:27][N:26]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[S:27]1[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[C:25]([N:19]2[CH2:20][CH2:21][N:22]([CH2:2][C:3]([C:5]3[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[C:7]([CH:15]([CH3:17])[CH3:16])[CH:6]=3)=[O:4])[CH2:23][CH2:24]2)=[N:26]1

Participants

3

Reactant 2

HCID 115217113-(1-Piperazinyl)-1,2-benzisothiazole monohydrochlorideHCID 21963588HCID 21963588, compound

Product 1

HCID 21963175HCID 21963175, compoundYield 55.1%

Procedure

Starting with N-[4-(2-Chloro-acetyl)-2-isopropyl-phenyl]-acetamide (0.380 g, 1.498 mmole), and 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (0.383 g, 1.498 mmole, 1.0 eq) and following the procedure as outlined in Example 17, N-{4-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-acetyl]-2-isopropyl-phenyl}-acetamide (0.360 g, 0.825 mmole) was obtained as its hydrochloride salt from treatment with dioxane/HCl(gas).

Sources & evidence

ORD record
ord-546af6266ce5437ab66439ee2dc6e040
Source dataset
uspto-grants-2006_09
Patent number
US07101886B2

Reaction notes

Loading…