2-Chloro-5-(chloromethyl)thiophene → 1-[4-[(5-Chlorothien-2-yl)methyl]morpholin-2-yl]methanamine

HRID 2211970Notes

Reaction equation

HRID 2211970 reaction equation
Cl[C:2]1[CH:3]=[C:4](C=C[C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.ClC1[S:20]C(CCl)=CC=1>>[Cl:17][C:16]1[S:20][C:4]([CH2:5][N:6]2[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 5830792-Chloro-5-(chloromethyl)thiopheneHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 219628881-[4-[(5-Chlorothien-2-yl)methyl]morpholin-2-yl]methanamine

Procedure

Intermediate 13 was prepared in an analogous manner to Intermediate 1 (Alternative procedure) from Intermediate 19 and 2-chloro-5-(chloromethyl)thiophene, followed by a deprotection reaction yielding the title compound.

Workup

  1. customfollowed by a deprotection reaction

Sources & evidence

ORD record
ord-189196f1f0294a6599cfc33c714682c6
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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