4-(Bromomethyl)-1,2-difluorobenzene → (4-(3,4-Difluorobenzyl)morpholin-2-yl)methanamine

HRID 2211972Notes

Reaction equation

HRID 2211972 reaction equation
ClC1C=C(C=CC=1Cl)CN1CCOC(CN)C1.FC(F)(F)C([NH:22][CH2:23][CH:24]1[O:29][CH2:28][CH2:27][NH:26][CH2:25]1)=O.[F:32][C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][C:40]=1[F:41])[CH2:36]Br>>[F:32][C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][C:40]=1[F:41])[CH2:36][N:26]1[CH2:27][CH2:28][O:29][CH:24]([CH2:23][NH2:22])[CH2:25]1

Participants

4

Reactant 3

HCID 5814364-(Bromomethyl)-1,2-difluorobenzeneHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamineHCID 115502612,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

Product 1

HCID 21962864(4-(3,4-Difluorobenzyl)morpholin-2-yl)methanamine

Procedure

Intermediate 20 was prepared in an analogous manner to Intermediate 1 (Alternative Procedure) from Intermediate 19 and 3,4-difluorobenzyl bromide, followed by deprotection to yield the title compound.

Sources & evidence

ORD record
ord-33fe560cd3bd470184c2850dccf1a9e5
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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