HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)-1,2-difluorobenzene → (4-(3,4-Difluorobenzyl)morpholin-2-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)-1,2-difluorobenzene | HCID 581436 | — |
| Reactant | [4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine | HCID 10308229 | — |
| Reactant | 2,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide | HCID 11550261 | — |
| Product | (4-(3,4-Difluorobenzyl)morpholin-2-yl)methanamine | HCID 21962864 | — |
Reaction Steps
Intermediate 20 was prepared in an analogous manner to Intermediate 1 (Alternative Procedure) from Intermediate 19 and 3,4-difluorobenzyl bromide, followed by deprotection to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07101882B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-33fe560cd3bd470184c2850dccf1a9e5 |
| Source note | uspto-grants-2006_09 |