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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2211973Generated: October 31, 2026

4-Fluorobenzyl chloride → 2-Aminomethyl-4-(4-fluorobenzyl)morpholine

https://huagongshe.com/reaction/2211973

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorobenzyl chlorideHCID 9602—
Reactant[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamineHCID 10308229—
Reactant2,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamideHCID 11550261—
Product2-Aminomethyl-4-(4-fluorobenzyl)morpholineHCID 10242735—

Reaction Steps

Intermediate 21 was prepared in an analogous manner to Intermediate 1 (Alternative Procedure) from Intermediate 19 and 4-fluorobenzyl chloride, followed by deprotection to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07101882B2
Source datasetuspto-grants-2006_09
ORD IDord-bcd1d0fa3cb84f6e83085878f292178d
Source noteuspto-grants-2006_09