4-Fluorobenzyl chloride → 2-Aminomethyl-4-(4-fluorobenzyl)morpholine

HRID 2211973Notes

Reaction equation

HRID 2211973 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1Cl)[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[F:18]C(F)(F)C(NCC1OCCNC1)=O.FC1C=CC(CCl)=CC=1>>[F:18][C:16]1[CH:15]=[CH:14][C:4]([CH2:5][N:6]2[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]2)=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 96024-Fluorobenzyl chlorideHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamineHCID 115502612,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

Product 1

HCID 102427352-Aminomethyl-4-(4-fluorobenzyl)morpholine

Procedure

Intermediate 21 was prepared in an analogous manner to Intermediate 1 (Alternative Procedure) from Intermediate 19 and 4-fluorobenzyl chloride, followed by deprotection to yield the title compound.

Sources & evidence

ORD record
ord-bcd1d0fa3cb84f6e83085878f292178d
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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