HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2211976Generated: October 30, 2026
Hydrochloric Acid → 1-[(2S)-4-(3,4-dichlorobenzoyl)morpholin-2-yl]methanamine hydrochloride
https://huagongshe.com/reaction/2211976
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl[(2S)-4-(3,4-dichlorobenzoyl)morpholin-2-yl]methylcarbamate | HCID 86760232 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-[(2S)-4-(3,4-dichlorobenzoyl)morpholin-2-yl]methanamine hydrochloride | HCID 68882702 | 183.8% |
Reaction Steps
Intermediate 30 (0.770 g) was treated with 4.0M hydrogen chloride in dioxane (8 ml). The mixture was stirred at 20° C. for 30 min. The solvent was removed in vacuo to give the title compound as a white solid (0.592 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07101882B2 |
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| Source dataset | uspto-grants-2006_09 |
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| ORD ID | ord-1a992fc617064fc48693493df50b25a2 |
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| Source note | uspto-grants-2006_09 |
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