Hydrochloric Acid → 1-[(2S)-4-(3,4-dichlorobenzoyl)morpholin-2-yl]methanamine hydrochloride

HRID 2211976Notes

Reaction equation

HRID 2211976 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[Cl:25])[C:5]([N:7]1[CH2:12][CH2:11][O:10][C@@H:9]([CH2:13][NH:14]C(=O)OC(C)(C)C)[CH2:8]1)=[O:6].Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[Cl:25])[C:5]([N:7]1[CH2:12][CH2:11][O:10][C@@H:9]([CH2:13][NH2:14])[CH2:8]1)=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86760232tert-Butyl[(2S)-4-(3,4-dichlorobenzoyl)morpholin-2-yl]methylcarbamate

Product 1

HCID 688827021-[(2S)-4-(3,4-dichlorobenzoyl)morpholin-2-yl]methanamine hydrochlorideYield 183.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
20 °C

Procedure

Intermediate 30 (0.770 g) was treated with 4.0M hydrogen chloride in dioxane (8 ml). The mixture was stirred at 20° C. for 30 min. The solvent was removed in vacuo to give the title compound as a white solid (0.592 g).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-1a992fc617064fc48693493df50b25a2
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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