2-(4-Fluoro-2-methylphenyl)acetic acid → N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-2-(4-fluoro-2-methylphenyl)acetamide

HRID 2211998Notes

Reaction equation

HRID 2211998 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](O)=[O:27])=[C:21]([CH3:29])[CH:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:26](=[O:27])[CH2:25][C:22]2[CH:23]=[CH:24][C:19]([F:18])=[CH:20][C:21]=2[CH3:29])[CH2:7]1

Participants

3

Reactant 2

HCID 50169502-(4-Fluoro-2-methylphenyl)acetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 21962785N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}-2-(4-fluoro-2-methylphenyl)acetamideYield 16.5%

Procedure

Example 19 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.055 g) and (4-fluoro-2-methylphenyl)acetic acid (0.034 g) to give the title compound (0.014 g).

Workup

  1. customExample 19 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-603c67d76085466497d5e22693b3a7a9
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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