2-(4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)acetic acid → 2-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide

HRID 2212006Notes

Reaction equation

HRID 2212006 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[Br:18][C:19]1[C:20]([CH3:29])=[N:21][N:22]([CH2:25][C:26](O)=[O:27])[C:23]=1[CH3:24]>>[Br:18][C:19]1[C:20]([CH3:29])=[N:21][N:22]([CH2:25][C:26]([NH:13][CH2:12][CH:8]2[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]3[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=3)[CH2:7]2)=[O:27])[C:23]=1[CH3:24]

Participants

3

Reactant 2

HCID 8196162-(4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)acetic acidHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

Product 1

HCID 219629912-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamideYield 32.4%

Procedure

Example 35 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 1 (0.056 g) and (4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)acetic acid (0.047 g) to give the title compound (0.032 g).

Workup

  1. customExample 35 was prepared in an analogous manner to Example 1 using

Sources & evidence

ORD record
ord-bda7c50451a94c7697c823097ce3ea16
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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