(3-((Methylsulfonyl)amino)phenyl)acetic acid → N-({(2R)-4-[(5-Chlorothien-2-yl)methyl]morpholin-2-yl}methyl)-2-{3-[(methylsulfonyl)amino]phenyl}acetamide

HRID 2212015Notes

Reaction equation

HRID 2212015 reaction equation
[Cl:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][NH2:15])[CH2:9]2)=[CH:4][CH:3]=1.[CH3:16][S:17]([NH:20][C:21]1[CH:22]=[C:23]([CH2:27][C:28](O)=[O:29])[CH:24]=[CH:25][CH:26]=1)(=[O:19])=[O:18]>>[Cl:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][NH:15][C:28](=[O:29])[CH2:27][C:23]3[CH:24]=[CH:25][CH:26]=[C:21]([NH:20][S:17]([CH3:16])(=[O:18])=[O:19])[CH:22]=3)[CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2773885(3-((Methylsulfonyl)amino)phenyl)acetic acidHCID 68881532HCID 68881532, compound

Product 1

HCID 68880571N-({(2R)-4-[(5-Chlorothien-2-yl)methyl]morpholin-2-yl}methyl)-2-{3-[(methylsulfonyl)amino]phenyl}acetamideYield 45.8%

Procedure

Example 50 was prepared in an analogous manner to Example 44 using a mixture of Intermediate 14A (0.1 g) and Intermediate 18(0.1 g) to give the title compound (0.085 g).

Workup

  1. customExample 50 was prepared in an analogous manner to Example 44 using

Sources & evidence

ORD record
ord-716c7d99ee114564b1c08488e190efa3
Source dataset
uspto-grants-2006_09
Patent number
US07101882B2

Reaction notes

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