Diethylamine → (S)-N-Ethyl-N-(pyrrolidin-2-ylmethyl)ethanamine

HRID 2212043Notes

Reaction equation

HRID 2212043 reaction equation
[N:1]1([CH2:6][C@@H:7]2[CH2:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(NCC)C>>[CH2:5]([N:1]([CH2:2][CH3:3])[CH2:6][C@@H:7]1[CH2:11][CH2:10][CH2:9][NH:8]1)[CH3:4]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine

Product 1

HCID 7141622(S)-N-Ethyl-N-(pyrrolidin-2-ylmethyl)ethanamine

Procedure

N,N-Diethyl-N-(((S)-pyrrolidin-2-yl)methyl)amine was synthesized as described for (S)-2-((pyrrolidin-1-yl)methyl)pyrrolidine starting with N,N-diethylamine instead of pyrrolidine.

Sources & evidence

ORD record
ord-718e75cbc338420b9673dabcb59f84e5
Source dataset
uspto-grants-2006_09
Patent number
US07101898B2

Reaction notes

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