Water → Cyclopropanesulphonylbenzene

HRID 2212062Notes

Reaction equation

HRID 2212062 reaction equation
[C:1]1([S:7][CH:8]2[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:11]OS([O-])=O.[K+].[OH2:17]>CO>[CH:8]1([S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:11])=[O:17])[CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 962WaterHCID 123348Benzene, (cyclopropylthio)-HCID 23707502Potassium hydroxy sulfite

Product 1

HCID 11309899Cyclopropanesulphonylbenzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of cyclopropyl phenyl sulfide (10.5 g, 70 mmol) and Oxone™ (55.13 g, 175 mmol) in methanol (30 ml) was stirred at room temperature for 5 hours. The mixture was diluted was water and extracted with ethyl acetate. The combined organic layers were dried (MgSO4) and concentrated in vacuo.

Workup

  1. additionThe mixture was diluted
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organic layers were dried (MgSO4)
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-cf85ed6b24364e7f880c4edaa04925ef
Source dataset
uspto-grants-2006_09
Patent number
US07101892B2

Reaction notes

Loading…