Hydrochloric Acid → HCID 58367796, compound

HRID 221228Notes

Reaction equation

HRID 221228 reaction equation
Cl.CO[CH:4]([O:21]C)[CH2:5][NH:6][C:7]([C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[CH:13][CH:12]=2)=[O:8]>CC(C)=O>[OH:21][CH:4]1[N:10]2[C:11]3[CH:12]=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][C:16]=3[CH:17]=[C:9]2[C:7](=[O:8])[NH:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68023578HCID 68023578, compound

Product 1

HCID 58367796HCID 58367796, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

HCl 2N (13.75 ml, 27.5 mmol, 2.5 eq.) was added to a solution of the compound of formula (IV) (3 g, 11 mmol, 1 eq.) in acetone (200 ml), the final solution was stirred at 25° C. for 48 h. The solution was dried under reduced pressure affording the compound of formula (V) as yellow solid that was used in the subsequent step without further purification. Same procedure on 30 g scale proceeded smoothly. Typical yield: 97%.

Workup

  1. customThe solution was dried under reduced pressure

Sources & evidence

ORD record
ord-1e4fdb4f25c54dd28b09453d7bcd6b23
Source dataset
uspto-grants-2012_06
Patent number
US08207165B2

Reaction notes

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