Hydrochloric Acid → HCID 21964201, compound

HRID 2212351Notes

Reaction equation

HRID 2212351 reaction equation
[ClH:1].[NH2:2][C:3]1[S:4][C:5]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:17]=2)=[C:6]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[CH:9]=2)[N:7]=1>CO>[ClH:1].[ClH:1].[NH2:2][C:3]1[S:4][C:5]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:17]=2)=[C:6]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[CH:9]=2)[N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 219641944-[2-Amino-4-(3,5-dimethylphenyl)-1,3-thiazol-5-yl]-N-benzylpyridin-2-amine

Product 1

HCID 21964201HCID 21964201, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A 10% solution of hydrogen chloride in methanol (10 mL) was added to a suspension of N-[4-[2-amino-4-(3,5-dimethylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzylamine (0.80 g, 2.1 mmol) in methanol (50 mL) and the mixture was stirred at room temperature for 5 hours. The solvent was distilled off and the residue was recrystallized from methanol-ethyl acetate to obtain 0.73 g (1.6 mmol, yield 76%) to obtain the title compound.

Workup

  1. distillationThe solvent was distilled off
  2. customthe residue was recrystallized from methanol-ethyl acetate
  3. customto obtain 0.73 g (1.6 mmol, yield 76%)

Sources & evidence

ORD record
ord-0a831d6748c646a9b9d25ce79c8496ed
Source dataset
uspto-grants-2006_09
Patent number
US07101899B1

Reaction notes

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