HCID 86602635, compound → HCID 90744006, compound

HRID 2212494Notes

Reaction equation

HRID 2212494 reaction equation
[Si:1]([O:8][C@@H:9]1[CH2:14][C@H:13]([OH:15])[CH2:12][CH2:11][C@H:10]1[NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]>CO>[Si:1]([O:8][C@H:9]1[CH2:14][C@@H:13]([OH:15])[CH2:12][CH2:11][C@@H:10]1[NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 86602635HCID 86602635, compound2×

Product 1

HCID 90744006HCID 90744006, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(1S,2S,4S)-4-(Benzyloxy)-2-(tert-butyldimethylsilyloxy)-N-((S)-1-phenylethyl)cyclohexanamine MS: 440 (M+H)+; HPLC Ret Time: 2.83 min (YMC Xterra S5 4.6×50 mm column, 3 min gradient, 4 mL/min) was obtained from (1S,2S,5S)-5-(benzyloxy)-2-((S)-1-phenylethylamino)-cyclohexanol) 39A as described in 39B. It was then converted to the product as described in 39B and exhibited an [a]25589 19.2 (c 5.7, MeOH).

Sources & evidence

ORD record
ord-92db866226ba42a4adc1fe7cefbeaf61
Source dataset
uspto-grants-2006_09
Patent number
US07102003B2

Reaction notes

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