1-Iodopropane → HCID 21966448, compound

HRID 2212613Notes

Reaction equation

[F:1][C:2]([F:26])([F:25])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][C:5]=1[C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:23])([CH3:22])[C:17](=[O:21])[NH:18]2)=[CH:14][C:13]=1[CH3:24].[CH2:27](I)[CH2:28][CH3:29]>>[F:26][C:2]([F:25])([F:1])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][C:5]=1[C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:22])([CH3:23])[C:17](=[O:21])[N:18]2[CH2:27][CH2:28][CH3:29])=[CH:14][C:13]=1[CH3:24]

Participants

Reactant 2

HCID 336431-Iodopropane

HCID 21966458HCID 21966458, compound

Product 1

HCID 21966448HCID 21966448, compound

Procedure

The intermediate 4-trifluoromethoxy-3-(3,3,5-trimethyl-2-oxo-1-propyl-2,3-dihydro-1H-indol-6-yl)-benzaldehyde was prepared in a similar manner to example 21a using 4-trifluoromethoxy-3-(3,3,5-trimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)-benzaldehyde (example 21b) and propyl iodide. 1H NMR (300 MHz, CDCl3, ppm): δ: 0.93(t, J=7.3 Hz, 3 H), 1.45(s, 6 H), 1.70(m, 2 H), 2.10(s, 3 H), 3.66 (m, 2 H), 6.63 (s, 1 H), 7.11 (s, 1 H), 7.52–7.55 (m, 1 H), 7.85 (m, 1 H), 7.98 (m, 1H), 10.05 (s, 1 H).

Sources & evidence

ORD record: ord-03b743f618c44e62b9f672c9dabc50cf
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07102000B2

Reaction notes

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