Isoeugenol → HCID 69589350, compound

HRID 2212886Notes

Reaction equation

HRID 2212886 reaction equation
C(C1[O:5]C1)Cl.[C:6]1([O:16][CH3:17])[C:7](=[CH:9][CH:10]=[C:11]([CH:15]=1)[CH:12]=[CH:13][CH3:14])[OH:8].[OH-].[Na+]>C(O)C>[O:5]1[C:12](=[CH:13][CH3:14])[C:11]2[CH:15]=[C:6]([O:16][CH3:17])[C:7]([OH:8])=[CH:9][C:10]1=2

Participants

5

Reactant 3

HCID 7338IsoeugenolHCID 7835EpichlorohydrinHCID 14798Sodium Hydroxide

Product 1

HCID 69589350HCID 69589350, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To manufacture this combination Epichlorohydrin was mixed with isoeugenol and NaOH dissolved in ethanol and boiled to reflux for 2–6 hours. Ethanol was then removed from the resulting mixture and the mixture was passed through silica gel column eluted with n-hexane and ethyl acetate, and dried with reduced pressure, to obtain 4-epoxy isoeugenol.

Workup

  1. temperatureto reflux for 2–6 hours
  2. customEthanol was then removed from the resulting mixture
  3. washeluted with n-hexane and ethyl acetate
  4. customdried with reduced pressure

Sources & evidence

ORD record
ord-73008e7bfd4246e0a4b7df7ffc23ced4
Source dataset
uspto-grants-2006_09
Patent number
US07105521B2

Reaction notes

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