Diphosgene → HCID 21956014, compound

HRID 2212960Notes

Reaction equation

HRID 2212960 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[CH2:6][NH:7][CH3:8].ClC([O:17][C:18]([Cl:21])(Cl)Cl)=O>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[CH2:6][N:7]([CH3:8])[C:18]([Cl:21])=[O:17]

Participants

4

Reactant 2

HCID 10426DiphosgeneHCID 592161(3,4-Dimethoxybenzyl)methylamine

Product 1

HCID 21956014HCID 21956014, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1.00 g (5.52 mmol) of 3,4-dimethoxybenzyl-N-methylamine (obtainable by reductive amination from 3,4-dimethoxybenzaldehyde) are dissolved in 20 ml of anhydrous pyridine. 0.60 g (0.37 mmol, 3.04 mmol) of trichloromethyl chloroformate (“diphosgene”) is added, and the mixture is left to stir at room temperature overnight. The solution is employed without workup directly in the next stage.

Workup

  1. waitthe mixture is left

Sources & evidence

ORD record
ord-9efe43d1a612430e9b378b2a5d86a5db
Source dataset
uspto-grants-2006_09
Patent number
US07105523B2

Reaction notes

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