Hydrochloric Acid → 1-Oxa-8-azaspiro(4.5)decane hydrochloride

HRID 2213017Notes

Reaction equation

HRID 2213017 reaction equation
[ClH:1].[O:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1>CO>[ClH:1].[O:2]1[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21955197tert-Butyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Product 1

HCID 219349811-Oxa-8-azaspiro(4.5)decane hydrochlorideYield 98%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanolic hydrogen chloride (3M, 20 mL) was added over 10 minutes to a stirred, cooled (0° C.) solution of 1,1-dimethylethyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate (Description 74, 3.18 g, 13.2 mmol) in methanol (10 mL) and the mixture was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure to give the title compound (2.29 g, 98%). m/z (ES+) 142 (M+1).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c357045e74d94ad2a49741150c27557f
Source dataset
uspto-grants-2006_09
Patent number
US07105507B2

Reaction notes

Loading…