2-(3,5-Bis(trifluoromethyl)phenyl)propanoic acid → HCID 21955387, compound

HRID 2213061Notes

Reaction equation

HRID 2213061 reaction equation
[CH3:1][CH:2]([C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([C:16]([F:19])([F:18])[F:17])[CH:7]=1)[C:3](O)=[O:4].Cl.[F:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2([NH2:35])[CH2:33][CH2:32][C:31](=[O:34])[CH2:30][CH2:29]2)=[CH:24][CH:23]=1>>[CH3:1][CH:2]([C:6]1[CH:11]=[C:10]([C:12]([F:13])([F:15])[F:14])[CH:9]=[C:8]([C:16]([F:17])([F:18])[F:19])[CH:7]=1)[C:3]([NH:35][C:28]1([C:25]2[CH:24]=[CH:23][C:22]([F:21])=[CH:27][CH:26]=2)[CH2:29][CH2:30][C:31](=[O:34])[CH2:32][CH2:33]1)=[O:4]

Participants

3

Reactant 2

HCID 115220582-(3,5-Bis(trifluoromethyl)phenyl)propanoic acidHCID 69559333HCID 69559333, compound

Product 1

HCID 21955387HCID 21955387, compound

Procedure

Prepared from (RS)-α-methyl-3,5-bis(trifluoromethyl)benzeneacetic acid (Description 4) and 1-(4-fluorophenyl)-4-oxocyclohexylamine hydrochloride (Description 182) according to the method of Example 1. 1H NMR (400 MHz, CDCl3) δ 7.81 (1H, s), 7.71 (2H, s), 7.29–7.25 (2H, m), 7.01–6.96 (2H, m), 5.73 (1H, s), 3.69 (1H, q, J 7.0 Hz), 2.80–2.77 (1H, m), 2.62–2.57 (1H, m), 2.44–2.28 (6H, m), and 1.51 (3H, d, J 7.0 Hz).

Sources & evidence

ORD record
ord-aaab2a6f028140b7adac01104df8ce54
Source dataset
uspto-grants-2006_09
Patent number
US07105507B2

Reaction notes

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