2-(3,5-Bis(trifluoromethyl)phenyl)propanoic acid → HCID 21955387, compound

Participants

Reaction Steps

Prepared from (RS)-α-methyl-3,5-bis(trifluoromethyl)benzeneacetic acid (Description 4) and 1-(4-fluorophenyl)-4-oxocyclohexylamine hydrochloride (Description 182) according to the method of Example 1. 1H NMR (400 MHz, CDCl3) δ 7.81 (1H, s), 7.71 (2H, s), 7.29–7.25 (2H, m), 7.01–6.96 (2H, m), 5.73 (1H, s), 3.69 (1H, q, J 7.0 Hz), 2.80–2.77 (1H, m), 2.62–2.57 (1H, m), 2.44–2.28 (6H, m), and 1.51 (3H, d, J 7.0 Hz).

Provenance & Evidence