反应详情

Hydrazine hydrate (0.3 mL, 5.9 mmol) was added to a stirred solution of 5-chloro-2-phenyl-isonicotinonitrile (420 mg, 1.9 mmol) in pyridine (5 mL). The reaction mixture was stirred at reflux for 3 hours, cooled and the resulting solid was filtered and dried in vacuo, affording a crude residue. Purification by column chromatography using a gradient elution of 0–5% methanol in dichloromethane as eluent afforded the title compound as a solid.

1. temperatureat reflux for 3 hours
2. temperaturecooled
3. filtrationthe resulting solid was filtered
4. customdried in vacuo
5. customaffording a crude residue
6. customPurification by column chromatography
7. washa gradient elution of 0–5% methanol in dichloromethane as eluent