HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyryl chloride → N-[5-(2,3-Difluorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]isobutyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyryl chloride | HCID 62325 | — |
| Reactant | 3-amino-5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyridine | HCID 21948267 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[5-(2,3-Difluorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]isobutyramide | HCID 21956502 | — |
Reaction Steps
5-(2,3-Difluorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-ylamine (Description 3; 100 mg, 0.41 mmol) was reacted with isobutyryl chloride (43 uL, 0.41 mmol) in pyridine (0.5 mL) in a manner analogous to that described in Example 1. Chromatography on silica gel using 4% v/v methanol in dichloromethane as eluent afforded the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07105532B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-806fff28dab34c73a6b534be41d57f7d |
| Source note | uspto-grants-2006_09 |