Isobutyryl chloride → N-[5-(2,3-Difluorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]isobutyramide

HRID 2213071Notes

Reaction equation

HRID 2213071 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]2[C:17]([NH2:18])=[N:16][NH:15][C:12]2=[CH:13][N:14]=1.[C:19](Cl)(=[O:23])[CH:20]([CH3:22])[CH3:21]>N1C=CC=CC=1.CO.ClCCl>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]2[C:17]([NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])=[N:16][NH:15][C:12]2=[CH:13][N:14]=1

Participants

6

Reactant 2

HCID 62325Isobutyryl chlorideHCID 219482673-amino-5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyridine

Product 1

HCID 21956502N-[5-(2,3-Difluorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]isobutyramide

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

5-(2,3-Difluorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-ylamine (Description 3; 100 mg, 0.41 mmol) was reacted with isobutyryl chloride (43 uL, 0.41 mmol) in pyridine (0.5 mL) in a manner analogous to that described in Example 1. Chromatography on silica gel using 4% v/v methanol in dichloromethane as eluent afforded the title compound as a solid.

Sources & evidence

ORD record
ord-806fff28dab34c73a6b534be41d57f7d
Source dataset
uspto-grants-2006_09
Patent number
US07105532B2

Reaction notes

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