反应详情

温度

150 °C

To a solution of 2,5,6-trichloro-N-tetrahydropyranyl-benzimidazole (213 mg, 0.70 mmol) and 1-methylsulfonylspiro[indoline-3,4′-piperidine] hydrochloride (168 mg, 0.56 mmol) in dioxane (10 mL) was added cesium carbonate (562 mg, 0.47 mmol). The mixture was stirred at 150° C. for 14 hours in a sealed tube and then cooled. After addition of water, the reaction mixture was extracted with ethyl acetate. The organic layer was dried over sodium sulfate, and concentrated in vacuo. The resulting residue was dissolved in methanol (10 mL), and camphor sulfonic acid (100 mg, 0.70 mmol) was added thereto, then stirred at room temperature for 12 hours. The reaction mixture was concentrated in vacuo, and the residue was neutralized with 0.1M aqueous sodium hydroxide, then extracted with chloroform. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The precipitate formed upon addition of ethyl acetate to the residue was collected by filtration and dried to give the title compound (86 mg, 34%).

1. temperaturecooled
2. extractionthe reaction mixture was extracted with ethyl acetate
3. dry with materialThe organic layer was dried over sodium sulfate
4. concentrationconcentrated in vacuo
5. dissolutionThe resulting residue was dissolved in methanol (10 mL)
6. stirringstirred at room temperature for 12 hours
7. concentrationThe reaction mixture was concentrated in vacuo
8. extractionextracted with chloroform
9. washThe organic layer was washed with brine
10. dry with materialdried over anhydrous sodium sulfate
11. concentrationconcentrated in vacuo
12. customThe precipitate formed upon addition of ethyl acetate to the residue
13. filtrationwas collected by filtration
14. customdried