反应详情

A solution of 1-(3-methoxy-4-pyridin-2-ylphenyl)propan-1-ol (134 mg, 0.55 mmol) was dissolved in CH2Cl2 (3 mL), DMSO (0.5 mL), Et3N (0.5 mL) and was treated with sulfur trioxide pyridine complex (350 mg, 2.2 mmol) at 0° C. for 12 h. The reaction mixture was diluted with water (10 mL) and the product was extracted into CH2Cl2 (3×10 mL), dried (MgSO4), concentrated and purified by flash column chromatography on silica gel eluting with EtOAc:hexanes (1:9 to 1:1) to afford 1-(3-methoxy-4-pyridin-2-ylphenyl)propan-1-one.

1. extractionthe product was extracted into CH2Cl2 (3×10 mL)
2. dry with materialdried (MgSO4)
3. concentrationconcentrated
4. custompurified by flash column chromatography on silica gel eluting with EtOAc:hexanes (1:9 to 1:1)