1-Boc-4-(aminomethyl)piperidine → HCID 21955493, compound

HRID 2213150Notes

Reaction equation

HRID 2213150 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH2:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>FC1C=CC=CN=1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][N:8]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 7368171-Boc-4-(aminomethyl)piperidine

Product 1

HCID 21955493HCID 21955493, compoundYield 147.1%

Reagents, catalysts & solvents 1

HCID 97462-FluoropyridineSolvent

Procedure

1-tert-Butyloxycarbonyl-4-(aminomethyl)piperidine (3 g; 14 mmol) and 10 ml of 2-fluoropyridine were heated to reflux for 4 h. Concentration and stirring of the crude product in n-pentane afforded 3 g of a white solid, melting point: 126–130° C.;

Workup

  1. temperatureto reflux for 4 h
  2. concentrationConcentration

Sources & evidence

ORD record
ord-da3e77ffe63c4073831fbb3cd015c583
Source dataset
uspto-grants-2006_09
Patent number
US07105508B1

Reaction notes

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