HCID 21912551, compound → HCID 86760242, compound

HRID 2213155Notes

Reaction equation

HRID 2213155 reaction equation
[CH3:1][O:2][C:3](=[O:25])[CH2:4][N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[N:8]([CH2:17][C:18]([OH:20])=O)[C:7]2[CH:21]=[CH:22][CH:23]=[CH:24][C:6]1=2.[NH2:26][CH2:27][C:28]1[N:29]=[C:30]([NH:33][C:34]([NH:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[O:35])[S:31][CH:32]=1>>[CH2:37]([NH:36][C:34]([NH:33][C:30]1[S:31][CH:32]=[C:28]([CH2:27][NH:26][C:18](=[O:20])[CH2:17][N:8]2[C:9](=[O:16])[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:5]([CH2:4][C:3]([O:2][CH3:1])=[O:25])[C:6]3[CH:24]=[CH:23][CH:22]=[CH:21][C:7]2=3)[N:29]=1)=[O:35])[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1

Participants

3

Reactant 2

HCID 21912551HCID 21912551, compoundHCID 21955404HCID 21955404, compound

Product 1

HCID 86760242HCID 86760242, compound

Procedure

Preparation took place in analogy to I.B.23 by reacting [5-(2-methoxy-2-oxoethyl)-11-oxo-5,11-dihydro-10H-dibenzo[b,e]-[1,4]diazepin-10-yl]acetic acid 37c with N-[4-(aminomethyl)1,3-thiazol-2-yl]-N′-benzylurea (hydrochloride) (38). Chromatography on silica gel (CH2Cl2/CH3OH 2→10%) afforded 0.45 g; ESI-MS [M+H+]=585.25.

Workup

  1. customPreparation
  2. customChromatography on silica gel (CH2Cl2/CH3OH 2→10%) afforded 0.45 g

Sources & evidence

ORD record
ord-aef6bbb5cedd421592a4e8b402ffc77b
Source dataset
uspto-grants-2006_09
Patent number
US07105508B1

Reaction notes

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