Hydrogen Bromide → HCID 21955745, compound

HRID 2213338Notes

Reaction equation

HRID 2213338 reaction equation
C(OC(=O)[NH:10][CH:11]1[C:17](=[O:18])[N:16]([CH3:19])[C:15]2[CH:20]=[CH:21][CH:22]=[CH:23][C:14]=2[C:13]([C:24]2[CH:29]=[CH:28][C:27]([C:30](=[O:32])[NH2:31])=[CH:26][CH:25]=2)=[N:12]1)C1C=CC=CC=1.Br>>[NH2:10][CH:11]1[C:17](=[O:18])[N:16]([CH3:19])[C:15]2[CH:20]=[CH:21][CH:22]=[CH:23][C:14]=2[C:13]([C:24]2[CH:25]=[CH:26][C:27]([C:30]([NH2:31])=[O:32])=[CH:28][CH:29]=2)=[N:12]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 69152125HCID 69152125, compound

Product 1

HCID 21955745HCID 21955745, compoundYield 80%

Procedure

To the product from Step 2C (400 mg, 0.9 mmol.) was added hydrogen bromide (45 wt % in acetic acid, 2 ml) and the mixture stirred until dissolution was complete (30 minutes). After this time, the orange solution was poured into ice cold ether (20 ml) and vigorously stirred for 10 minutes. The resulting precipitate was filtered and washed with cold ether to give the title compound (220 mg, 80%) as the hydrobromide salt.

Workup

  1. custom(30 minutes)
  2. stirringvigorously stirred for 10 minutes
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with cold ether

Sources & evidence

ORD record
ord-0e2929a31b5a44eb805c61a38576055f
Source dataset
uspto-grants-2006_09
Patent number
US07105509B2

Reaction notes

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