Methyl iodide → HCID 69633142, compound

HRID 2213344Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C@H:10]([CH3:33])[C:11]([NH:13][CH:14]2[C:20](=[O:21])[NH:19][C:18]3[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:17]=3[C:16]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[N:15]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:34]I>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C@H:10]([CH3:33])[C:11]([NH:13][CH:14]2[C:20](=[O:21])[N:19]([CH3:34])[C:18]3[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:17]=3[C:16]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[N:15]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 69633172HCID 69633172, compound

Product 1

HCID 69633142HCID 69633142, compound

Procedure

Prepared from (2S)-3-(3,4-dichlorophenyl)-2-methyl-N-(7-chloro-2-oxo-5phenyl-2,3dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide by treatment with methyl iodide (c.f Step 2B, Scheme 2) (1H, CDCl3) 1.27 (3H, d, J=7 Hz), 2.68 (2H, m), 2.96 (1H, m), 3.43 (3H, s), 5.41 (1H, d, J=7.9 Hz), 7.05 (1H, m), 7.14 (1H, m), 7.32–7.36 (4H, m), 7.41 (2H, m), 7.48 (1H, m), 7.54–7.58 (3H, m); MS(CI+): MH+:516.

Sources & evidence

ORD record: ord-c5a510a950fc428f8ba619a595767209
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07105509B2

Reaction notes

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