反应详情

Trifluoroacetic acid (6.5 ml) was added to a solution of (3-pyridin-4-yl-[1,2,4]oxadiazol-5-ylmethyl)carbamic acid tert-butyl ester (Preparation 8, 420 mg, 1.52 mmol in CH2Cl2 (10 ml) and the mixture stirred at rt for 2 h. The solvent was evaporated and the residue dissolved in EtOAc (100 ml). After washing with saturated aqueous Na2CO3 (25 ml), the aqueous phase was re-extracted with 5% MeOH in CH2Cl2 (7×25 ml) and the combined organic phases dried (MgSO4). The solvent was removed to afford the title compound: RT=0.25 min; m/z (ES+)=177.1 [M+H]+.

1. customThe solvent was evaporated
2. dissolutionthe residue dissolved in EtOAc (100 ml)
3. washAfter washing with saturated aqueous Na2CO3 (25 ml)
4. extractionthe aqueous phase was re-extracted with 5% MeOH in CH2Cl2 (7×25 ml)
5. dry with materialthe combined organic phases dried (MgSO4)
6. customThe solvent was removed