Bis(4-chlorophenyl)acetic acid → N-(3-{4-[3-(Acetylamino)phenyl]-1-piperidinyl}propyl)-2,2-bis(4-chloro phenyl)acetamide

Participants

Reaction Steps

Example 55 was prepared from bis(4-chlorophenyl)acetic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}acetamide according procedures described in Scheme 10: 1H NMR (400 MHz, CDCl3) δ 7.48 (s, 1H), 7.39 (br s, 1H), 7.31–7.22 (m, 11H), 6.94–6.92 (m, 1H), 4.76 (s, 1H), 3.39 (dd, 2H, J=6.4, 12.0 Hz), 2.97 (d, 2H, J=10.0 Hz), 2.49 (m, 1H), 2.44 (t, 2H, J=6.4 Hz), 2.17 (s, 3H), 2.05–1.99 (m, 2H), 1.83 (d, 2H, J=13.2 Hz), 1.71 (m, 2H), 1.61 (m, 2H); ESMS m/e: 538.3 (M+H)+.

Provenance & Evidence