1-(p-Chlorophenyl)cyclopropanecarboxylic acid → 1-(4-Chlorophenyl)-N-(3-{4-[3-(propionylamino)phenyl]-1-piperidinyl}propyl)cyclopropanecarboxamide

HRID 2213434Notes

Reaction equation

HRID 2213434 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]([OH:13])=O)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:25]=[C:26]([NH:30][C:31](=[O:34])[CH2:32][CH3:33])[CH:27]=[CH:28][CH:29]=2)[CH2:20][CH2:19]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]([NH:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][CH:21]([C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([NH:30][C:31](=[O:34])[CH2:32][CH3:33])[CH:25]=4)[CH2:20][CH2:19]3)=[O:13])[CH2:9][CH2:10]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 986061-(p-Chlorophenyl)cyclopropanecarboxylic acidHCID 21957142N-{3-[1-(3-aminopropyl)4-piperidinyl]phenyl}propanamide

Product 1

HCID 219572181-(4-Chlorophenyl)-N-(3-{4-[3-(propionylamino)phenyl]-1-piperidinyl}propyl)cyclopropanecarboxamide

Procedure

Example 63 was prepared from 1-(4-chlorophenyl)cyclopropanecarboxylic acid and N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}propanamide according to the procedures described in Scheme 10: ESMS m/e: 468.3 (M+H)+.

Sources & evidence

ORD record
ord-0bd8f1b421d3452faae8327390027cf1
Source dataset
uspto-grants-2006_09
Patent number
US07105544B2

Reaction notes

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